The best charities for fighting heart disease in terms of overall impact are the American Heart Association and the Children’s Heart Foundation. Charities such as Mended Hearts and WomenHeart do amazing work providing emotional support to people with heart disease. 

The best charities for protecting the Amazon rainforest in terms of overall impact are the Rainforest Trust and Amazon Conservation. Charities such as Survival International and the Amazon Conservation Team campaign heavily for the rights of indigenous Amazon peoples. 

The best charities for first responders are the Gary Sinise Foundation, Operation Gratitude, and Stephen Siller Tunnel to Towers Foundation. These charities provide mental and physical support services to first responders. They also honor fallen first responders and offer aid to their families.

The best charities to help premature babies are the Genesis Research Trust and Brave Beginnings. Charities such as Project Sweet Peas and Miracle Babies do amazing work providing vital care packages to struggling families with premature babies. 

The best charities for marine conservation in terms of overall impact are Oceana and the Marine Conservation Institute. Charities such as Monterey Bay Aquarium and the Marine Mammal Center do amazing work caring for and rehabilitating marine animals in need.

The best charities for helping homeless youth are Covenant House, the National Homelessness Law Center, and True Colors United. These charities campaign for more protection of at-risk youth. They also advocate for policy changes and early intervention methods to prevent youth from becoming homeless.

The best charities for Down syndrome support are the Arc and the Global Down Syndrome Foundation. Charities such as PATH International and the STAR Institute do amazing work providing individualized care for children with Down Syndrome, to aid their development. 

The best charities for helping refugees are the International Rescue Committee, Lutheran Immigration and Refugee Service, and Doctors Without Borders. These charities advocate for refugee protection, safety, and rights. They also deliver emergency relief and support services to refugees in need.

The best charities for climate change in terms of overall impact are Cool Earth and the Clean Air Task Force. Charities such as the Rainforest Alliance and Practical Action do amazing work training farmers in sustainable agriculture methods. 

The best charities for helping immigrants are Catholic Charities USA, Lutheran Immigration and Refugee Service, and the International Rescue Committee. These charities advocate for immigrants’ rights, safety, and protection. They also work to eliminate discrimination against immigrant communities.